Injection-free Oraqix® ...avoiding needle discomfort. Providing practitioners with a flexible approach for scaling and/or root planing procedures.
Product Description 
Oraqix® (lidocaine and prilocaine periodontal gel) 2.5%/ 2.5% is a microemulsion in which the oil phase is a eutectic mixture of lidocaine (2.5%) and prilocaine ( 2.5%) in a ratio of 1:1 by weight. It is available in a 5% strength and consists of equal concentrations of lidocaine and prilocaine (25 + 25 mg/g).
This eutectic mixture has a melting point below room temperature, therefore both local anesthetics exist as liquid oils rather than as crystals. Oraqix contains poloxamer excipients, which show reversible temperature-dependent gelation.
Together with the lidocaine-prilocaine 1:1 mixture, the poloxamers form a low-viscosity fluid system at room temperature and an elastic gel in the periodontal pocket.
The Oraqix single-use glass cartridges provide 1.7 g of gel (42.5 mg of lidocaine and 42.5 mg of prilocaine).
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NOTE: Do not inject. Oraqix is not intended for use with standard dental anesthetic syringes. Only use this product with the OraqixTM Dispenser, which is available from DENTSPLY Pharmaceutical. Do not use a dental cartridge warmer. The heat may cause the product to gel.
OraqixTM Dispenser Directions for Use (PDF document) |
Product Chemistry - Structural formulas & Drug Information
Lidocaine - C14H22N2O
Lidocaine is chemically designated as 2-(diethylamino)-N-(2,6-dimethylphenyl)-acetamide and has an octanol: water partition ratio of 43 at pH 7.4. The pKa of lidocaine is 7.86.
Prilocaine - C13H20N2O
Prilocaine is chemically designated as N-(2-methyl-phenyl)-2-(propylamino)-propanamide and has an octanol: water partition ratio of 25 at pH 7.4. The pKa of prilocaine is 7.89.
Each gram of Oraqix contains 25-mg lidocaine base and 25-mg prilocaine base. The gel also contains thermosetting agents (poloxamer 188 purified, poloxamer 407 purified), hydrochloric acid (pH adjustment), and purified water. The pH of Oraqix is 7.5-8.0. |
