Oraqix has been researched and evaluated for safety and efficacy.
In this section you can access published articles for each of five studies that have been conducted evaluating the efficacy of Oraqix. There are differences between the abstracts, the completed published articles and the summary that appears in the full prescribing information. Important information relating to contraindications, warnings, precautions, adverse reactions, dosage, and administration are not included in the published abstracts. Please refer to the full prescribing information.
Oraqix is indicated for adults who require localized anesthesia during scaling and/or root planing. Oraqix is not for injection. Oraqix is contraindicated in patients with a known history of hypersensitivity to local anesthesia of the amide type or any other component of this product. The most common adverse reactions in clinical studies were application site reactions, headaches and taste perversion. Oraqix should not be used in those patients with congenital or idiopathic methemoglobinemia. There are no adequate and well-controlled studies in pregnant women. Oraqix should be used during pregnancy only if the benefits outweigh the risks. Reproduction studies on the Oraqix drug product, including the inactive ingredients, have not been conducted. Lidocaine and possibly, Prilocaine are excreted in breast milk. Caution should be exercised when Oraqix is administed to nursing women. For complete Oraqix prescribing information, warnings and contraindications, see the warnings and contraindications tab.
The Anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix®) for periodontal scaling/root planing
- Johan Friskopp, Marie Nilsson and Goran Isacsson,
Journal of Clinical Periodontology 2001
"A new non-injection anesthetic, lidocaine/prilocaine gel (Oraqix®) in a reversible thermosetting system, has been developed to provide local anesthesia for scaling/root planing (SRP)..." download PDF for more
Plasma levels of lidocaine and prilocaine after application of Oraqix®, a new intrapocket anesthetic, in patients with advanced periodontitis
- Johan Friskopp and Gunilla Huledal,
Journal of Clinical Periodontology 2001
"Oraqix®, a new non-injection local anesthetic, lidocaine/prilocaine gel 5%, has been developed to provide pain relief in association with periodontal probing and scaling/root planing (SRP)..." download PDF for more
A placebo-controlled multi-centered evaluation of an anesthetic gel (Oraqix®) for periodontal therapy
- D. Donaldson, S.C. Gelskey, R.G. Landry, D.C. Matthews
and H.S. Sandhu, Journal of Clinical Periodontology 2003
"Six Canadian dental schools investigated the ability of a thermosetting gel containing 25 mg/g prilocaine and 25 mg/g lidocaine as active agents to produce analgesia in periodontal pockets..." download PDF for more
Intrapocket Anesthesia for Scaling and Root Planing: Results of a Double-Blind Multicenter Trial Using Lidocaine Prilocaine Dental Gel
- Marjorie K. Jeffcoat, Nico C. Geurs, Ingvar Magnusson,
Simon R. MacNeill, Nancy Mickels, Frank Roberts,
Peter Robinson, Afshin Salamati, and Ray Yukna,
Journal of Periodontology July 2001
"The efficacy of a novel anesthetic gel (lidocaine 25 mg/g plus prilocaine 25 mg/g in thermosetting agents) for non-invasive periodontal pocket anesthesia was evaluated..." download PDF for more
Patient Evaluation of a Novel Non-Injectable Anesthetic Gel: A Multicenter Crossover Study Comparing the Gel to Infiltration
- Daniel van Steenberghe, Pierre Bercy, Jan De Boever,
Patrick Adriaens, Lut Geers, Elke Hendrickx, Christian Adriaenssen,
Eric Rompen, Maria Malmenas, and Joakim Ramsberg,
Journal of Periodontology November 2004
"Periodontal scaling procedures commonly require some kind of anesthesia. From the patient's perspective, the choice of anesthetic method is a trade-off between the degree of anesthesia and accepting the side effects..." download PDF for more